About InVivoSIM anti-human CD38 (Isatuximab Biosimilar) This non-therapeutic biosimilar antibody uses the same variable regions as the therapeutic antibody Isatuximab, making it ideal for research use. Isatuximab is a chimeric IgG1 monoclonal antibody that specifically targets human CD38, a multifunctional transmembrane glycoprotein highly expressed on malignant plasma cells and other hematologic tumor cells, but also found at lower levels on subsets of immune cells such as NK cells, regulatory T cells, B cells, and some myeloid cells. CD38 has both receptor and ectoenzyme functions, contributing to cell adhesion, signal transduction, calcium mobilization, and NAD+ metabolism. By binding CD38, Isatuximab induces tumor cell death through multiple mechanisms including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and direct pro-apoptotic signaling. In the clinic, Isatuximab is approved for the treatment of multiple myeloma, where it has shown efficacy in reducing tumor burden and extending survival when combined with standard-of-care therapies. This Isatuximab biosimilar is well suited for studying CD38 signaling, plasma cell biology, tumor immunology, immune regulation, and therapeutic strategies targeting multiple myeloma and other CD38-positive malignancies. InVivoSIM anti-human CD38 (Isatuximab Biosimilar) Specifications IsotypeHuman IgG1, κ Recommended Isotype Control(s)RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer ImmunogenHuman CD38 Reported Applicationsin vivo functional assays in vitro functional assays ELISA Flow cytometry FormulationPBS, pH 7.0 Contains no stabilizers or preservatives Endotoxin≤0.5EU/mg (≤0.0005EU/μg)Determined by LAL gel clotting assay Aggregation<5% Determined by SEC Purity≥95%Determined by SDS-PAGE Sterility0.2 μm filtration ProductionPurified from cell culture supernatant in an animal-free facility PurificationProtein A Molecular Weight150 kDa StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
