{"id":"455","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"InVivoSIM anti-human integrin \u03b14\u03b21 (VLA-4)","post_excerpt":"This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Natalizumab making it ideal for research use. This Natalizumab biosimilar reacts with human VLA-4 \u03b1 chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. Integrin \u03b14 associates with integrin \u03b27 to form integrin \u03b14\u03b27 also known as LPAM-1 as well as integrin \u03b21 (CD29) to form integrin \u03b14\u03b21 also known as VLA-4. Integrin \u03b14 plays roles in adhesion and T cell co-stimulation. Integrin \u03b14 ligands include VCAM-1, MAdCAM-1, and fibronectin.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"invivosim-anti-human-integrin-41-vla-4-sim0018","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"SIM0018","path":"\/product\/invivosim-anti-human-integrin-41-vla-4-sim0018\/","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-sim0018-invivosim-anti-human-integrin-alpha4beta1-vla-4.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Human IgG4, \u03ba","immunogen":"Human integrin \u03b14\u03b27","reported_applications":"<ul><li>Functional assays<\/li><li>Flow cytometry<\/li><\/ul>","aggregation":"<5%\nDetermined by SEC","formulation":"<ul><li>PBS, pH 7.0<\/li><li>Contains no stabilizers or preservatives<\/li><\/ul>","murine_pathogen_tests":"<ul><li>Mouse Norovirus: Negative<\/li><li>Mouse Parvovirus: Negative<\/li><li>Mouse Minute Virus: Negative<\/li><li>Mouse Hepatitis Virus: Negative<\/li><li>Reovirus Screen: Negative<\/li><li>Lymphocytic Choriomeningitis virus: Negative<\/li><li>Lactate Dehydrogenase-Elevating Virus: Negative<\/li><li>Mouse Rotavirus: Negative<\/li><li>Theiler's Murine Encephalomyelitis: Negative<\/li><li>Ectromelia\/Mousepox Virus: Negative<\/li><li>Hantavirus: Negative<\/li><li>Polyoma Virus: Negative<\/li><li>Mouse Adenovirus: Negative<\/li><li>Sendai Virus: Negative<\/li><li>Mycoplasma Pulmonis: Negative<\/li><li>Pneumonia Virus of Mice: Negative<\/li><li>Mouse Cytomegalovirus: Negative<\/li><li>K Virus: Negative<\/li><\/ul>","human_pathogen_tests":null,"toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtered","production":null,"purification":"Protein G","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"AB_2927534","recommended_isotype_control":"<a href=\"\/product\/\">InVivoMAb polyclonal human IgG<\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"Natalizumab","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/SIM0018\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-13 02:10:06","active":"Y"}

InVivoSIM anti-human integrin α4β1 (VLA-4)

Clone	Catalog #	Category
Natalizumab	SIM0018

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human integrin α4β1 (VLA-4)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Natalizumab making it ideal for research use. This Natalizumab biosimilar reacts with human VLA-4 α chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. Integrin α4 associates with integrin β7 to form integrin α4β7 also known as LPAM-1 as well as integrin β1 (CD29) to form integrin α4β1 also known as VLA-4. Integrin α4 plays roles in adhesion and T cell co-stimulation. Integrin α4 ligands include VCAM-1, MAdCAM-1, and fibronectin.

InVivoSIM anti-human integrin α4β1 (VLA-4) Specifications

Isotype	Human IgG4, κ
Recommended Isotype Control(s)	InVivoMAb polyclonal human IgG
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human integrin α4β7
Reported Applications	Functional assays Flow cytometry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtered
Purification	Protein G
RRID	AB_2927534
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.