{"id":"562","post_author":null,"post_date":null,"post_date_gmt":null,"post_content":null,"post_title":"InVivoSIM anti-human nectin-4 (Enfortumab Biosimilar)","post_excerpt":"This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Enfortumab making it ideal for research use. This Enfortumab biosimilar reacts human nectin-4, also known as poliovirus receptor-related protein 4 (PVRL4). Nectin-4 belongs to the nectin family of cell adhesion molecules and plays a vital role in cell-cell adhesion. Nectin-4 is primarily expressed by epithelial cells, including those of the urinary bladder, lung, and breast tissue. It is involved in various biological processes such as tissue integrity maintenance, epithelial polarization, and immune response regulation. In recent years, nectin-4 has gained considerable attention in the context of cancer therapy, with the development of enfortumab vedotin, an antibody-drug conjugate that targets nectin-4, demonstrating promising results in the treatment of certain types of advanced urothelial cancers. This Enfortumab biosimilar antibody is only the antibody portion of Enfortumab vedotin and does not contain the drug conjugate.","post_status":"publish","comment_status":null,"ping_status":null,"post_password":null,"post_name":"invivosim-anti-human-nectin-4-enfortumab-biosimilar-sim0031","to_ping":null,"pinged":null,"post_modified":null,"post_modified_gmt":null,"post_content_filtered":null,"post_parent":null,"guid":null,"menu_order":null,"post_type":null,"post_mime_type":null,"comment_count":null,"filter":null,"sku":"SIM0031","path":"\/product\/invivosim-anti-human-nectin-4-enfortumab-biosimilar-sim0031\/","image":"https:\/\/pneuma.bioxcell.com\/Media\/Products\/bioxcell-sim0031-invivosim-anti-human-nectin-4-enfortumab-biosimilar.png","brand_id":null,"brand_name":null,"brand_slug":null,"brand_description":null,"isotype":"Human IgG1, \u03ba","immunogen":"Human nectin-4","reported_applications":"Functional assays\nELISA\nWestern blot","aggregation":"<5%\nDetermined by SEC","formulation":"PBS, pH 7.0\nContains no stabilizers or preservatives","murine_pathogen_tests":"Mouse Norovirus: Negative\nMouse Parvovirus: Negative\nMouse Minute Virus: Negative\nMouse Hepatitis Virus: Negative\nReovirus Screen: Negative\nLymphocytic Choriomeningitis virus: Negative\nLactate Dehydrogenase-Elevating Virus: Negative\nMouse Rotavirus: Negative\nTheiler's Murine Encephalomyelitis: Negative\nEctromelia\/Mousepox Virus: Negative\nHantavirus: Negative\nPolyoma Virus: Negative\nMouse Adenovirus: Negative\nSendai Virus: Negative\nMycoplasma Pulmonis: Negative\nPneumonia Virus of Mice: Negative\nMouse Cytomegalovirus: Negative\nK Virus: Negative","human_pathogen_tests":"","toxicity_test_results":null,"endotoxin":"<ul><li>\u22640.5EU\/mg (\u22640.0005EU\/\u03bcg)<\/li><li>Determined by LAL gel clotting assay<\/li><\/ul>","purity":"<ul><li>\u226595%<\/li><li>Determined by SDS-PAGE<\/li><\/ul>","sterility":"0.2 \u03bcm filtration","production":"Purified from cell culture supernatant in an animal-free facility","purification":"Protein A","composition":null,"volume":null,"concentration":null,"molecular_weight":"150 kDa","storage":"The antibody solution should be stored at the stock concentration at 4\u00b0C. Do not freeze.","rrid":"","recommended_isotype_control":"<a href=\"\/product\/\">RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme<\/a>","recommended_dilution_buffer":"<a href=\"\/product\/\">InVivoPure pH 7.0 Dilution Buffer<\/a>","clone":"Enfortumab","technical_data_sheet":"https:\/\/pneuma.bioxcell.com\/api\/v1\/products\/certificate-of-analysis\/SIM0031\/0\/0\/0?apikey=23D50188E6F74755AFFBF95BD41B140B","western_blot_image":null,"new_product_image":null,"product_references":null,"display_pubmed_logo":null,"modified":"2026-03-13 02:10:06","active":"Y"}

InVivoSIM anti-human nectin-4 (Enfortumab Biosimilar)

Clone	Catalog #	Category
Enfortumab	SIM0031

USD 235 - USD 8140

Technical Data Sheet

SDS Sheet

About InVivoSIM anti-human nectin-4 (Enfortumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Enfortumab making it ideal for research use. This Enfortumab biosimilar reacts human nectin-4, also known as poliovirus receptor-related protein 4 (PVRL4). Nectin-4 belongs to the nectin family of cell adhesion molecules and plays a vital role in cell-cell adhesion. Nectin-4 is primarily expressed by epithelial cells, including those of the urinary bladder, lung, and breast tissue. It is involved in various biological processes such as tissue integrity maintenance, epithelial polarization, and immune response regulation. In recent years, nectin-4 has gained considerable attention in the context of cancer therapy, with the development of enfortumab vedotin, an antibody-drug conjugate that targets nectin-4, demonstrating promising results in the treatment of certain types of advanced urothelial cancers. This Enfortumab biosimilar antibody is only the antibody portion of Enfortumab vedotin and does not contain the drug conjugate.

InVivoSIM anti-human nectin-4 (Enfortumab Biosimilar) Specifications

Isotype	Human IgG1, κ
Recommended Isotype Control(s)	RecombiMAb human IgG1 isotype control, anti-hen egg lysozyme
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Immunogen	Human nectin-4
Reported Applications	Functional assays ELISA Western blot
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	≤0.5EU/mg (≤0.0005EU/μg) Determined by LAL gel clotting assay
Aggregation	<5% Determined by SEC
Purity	≥95% Determined by SDS-PAGE
Sterility	0.2 μm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.