About InVivoSIM anti-human CD326 (EpCAM) (Edrecolomab Biosimilar) This biosimilar antibody uses the same variable regions as the therapeutic antibody Edrecolomab, making it ideal for research use. Edrecolomab is a murine monoclonal antibody which reacts with tumor-associated epithelial cell adhesion molecule (EpCAM), also known as CD326 and 17-1A. EpCAM is a 40-42 kDa cell-surface type 1 transmembrane glycoprotein expressed on most epithelial cells as well as a small subset of peripheral T cells, keratinocytes, Langerhans cells and thymic, lymph node, and splenic dendritic cells. EpCAM is also expressed by various carcinomas, including those of the colon and breast. CD326 mediates cell-cell adhesion and may function as a growth factor receptor. Upon binding to EpCAM, Edrecolomab recruits the body's immune effector cells, which may exhibit antitumor cytotoxicity. InVivoSIM anti-human CD326 (EpCAM) (Edrecolomab Biosimilar) Specifications IsotypeMouse IgG2a, κ Recommended Isotype Control(s)InVivoPlus mouse IgG2a isotype control, unknown specificity Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer ImmunogenHuman CD326 Reported ApplicationsFunctional assays ELISA Flow cytometry FormulationPBS, pH 7.0 Contains no stabilizers or preservatives Endotoxin<0.5EU/mg (<0.0005EU/μg) Determined by LAL gel clotting assay Aggregation<5% Determined by SEC Purity>95% Determined by SDS-PAGE Sterility0.2 μm filtration ProductionPurified from cell culture supernatant in an animal-free facility Molecular Weight150 kDa StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
