Posted on July 1, 2020 09:29
InVivoMAb anti-mouse NKG2D (CD314) (Clone: CX5)
The CX5 monoclonal antibody reacts with mouse NKG2D, a type II transmembrane lectin-like glycoprotein also known as CD314. NKG2D is expressed on NK cells, NKT cells, CD8 T cells, Î³/Î´ T cells, and macrophages. NKG2D has been implicated in anti-tumor surveillance, the immune response against viral infection, and in diabetes progression in NOD mice. Previous studies have shown that CX5 is a non-depleting antibody, which blocks binding of NKG2D to its ligands and mediates internalization of the receptor.
This Antibody Is Useful For:
in vivo NKG2D blockade
in vitro NKG2D blockade
ALWAYS specifically formulated for in vivo use and feature:
Ultra-low endotoxin levels
Preservative, stabilizer, and carrier protein-free
Recommended Control and Buffer:
InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
The HRPN monoclonal antibody reacts with horseradish peroxidase (HRP). Because HRP is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG1 antibodies in most in vivo and in vitro applications.
InVivoPure pH 7.0 Dilution Buffer
InVivoPureâ¢Â dilution buffers are specifically formulated and tested to satisfy the stringent requirements forÂ in vivoÂ applications. They are extremely low in endotoxin, have been screened for murine pathogens, tested in animal models for toxicity and are formulated with respect to buffer composition and pH to satisfy the requirements of Bio X Cellâs antibodies.